The cytoplasmic body: Another structural anomaly of the Z disk

Ronald D. Macdonald, Andrew G. Engel

Research output: Contribution to journalArticlepeer-review

72 Scopus citations


The "cytoplasmic body", herein described, represents another basic pathological reaction of the Z disk. It is characterized by (1) its origin in the Z disk, (2) a dense filamentous core, (3) a surrounding lighter halo, (4) randomly orientated thin and finer filaments in the halo, (5) lack of a tetragonal filamentous array regardless of the plane of the section, (6) an accompanying focal decrease of mitochrondria from the affected fibre regions, and (7) its restriction to white (type 2) fibres. These features are compared with those of other anomalies of the Z disk.

Original languageEnglish (US)
Pages (from-to)99-107
Number of pages9
JournalActa neuropathologica
Issue number2
StatePublished - Jun 1969


  • Cytoplasmic Body
  • Rods of Z-Disk Origin
  • Z Disk
  • Z-Disk Streaming

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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