The Crucial Role of the Interstitial Cells of Cajal in Neurointestinal Diseases

Egan L. Choi; Negar Taheri; Elijah Tan; Kenjiro Matsumoto; Yujiro Hayashi

doi:10.3390/biom13091358

The Crucial Role of the Interstitial Cells of Cajal in Neurointestinal Diseases

Egan L. Choi, Negar Taheri, Elijah Tan, Kenjiro Matsumoto, Yujiro Hayashi

Physiology & Biomedical Engineering

Research output: Contribution to journal › Review article › peer-review

Abstract

Neurointestinal diseases result from dysregulated interactions between the nervous system and the gastrointestinal (GI) tract, leading to conditions such as Hirschsprung’s disease and irritable bowel syndrome. These disorders affect many people, significantly diminishing their quality of life and overall health. Central to GI motility are the interstitial cells of Cajal (ICC), which play a key role in muscle contractions and neuromuscular transmission. This review highlights the role of ICC in neurointestinal diseases, revealing their association with various GI ailments. Understanding the functions of the ICC could lead to innovative perspectives on the modulation of GI motility and introduce new therapeutic paradigms. These insights have the potential to enhance efforts to combat neurointestinal diseases and may lead to interventions that could alleviate or even reverse these conditions.

Original language	English (US)
Article number	1358
Journal	Biomolecules
Volume	13
Issue number	9
DOIs	https://doi.org/10.3390/biom13091358
State	Published - Sep 2023

Keywords

gastrointestinal motility
interstitial cells of Cajal
neurointestinal diseases

ASJC Scopus subject areas

Biochemistry
Molecular Biology

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10.3390/biom13091358

Cite this

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title = "The Crucial Role of the Interstitial Cells of Cajal in Neurointestinal Diseases",

abstract = "Neurointestinal diseases result from dysregulated interactions between the nervous system and the gastrointestinal (GI) tract, leading to conditions such as Hirschsprung{\textquoteright}s disease and irritable bowel syndrome. These disorders affect many people, significantly diminishing their quality of life and overall health. Central to GI motility are the interstitial cells of Cajal (ICC), which play a key role in muscle contractions and neuromuscular transmission. This review highlights the role of ICC in neurointestinal diseases, revealing their association with various GI ailments. Understanding the functions of the ICC could lead to innovative perspectives on the modulation of GI motility and introduce new therapeutic paradigms. These insights have the potential to enhance efforts to combat neurointestinal diseases and may lead to interventions that could alleviate or even reverse these conditions.",

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AU - Choi, Egan L.

AU - Taheri, Negar

AU - Tan, Elijah

AU - Matsumoto, Kenjiro

AU - Hayashi, Yujiro

PY - 2023/9

Y1 - 2023/9

N2 - Neurointestinal diseases result from dysregulated interactions between the nervous system and the gastrointestinal (GI) tract, leading to conditions such as Hirschsprung’s disease and irritable bowel syndrome. These disorders affect many people, significantly diminishing their quality of life and overall health. Central to GI motility are the interstitial cells of Cajal (ICC), which play a key role in muscle contractions and neuromuscular transmission. This review highlights the role of ICC in neurointestinal diseases, revealing their association with various GI ailments. Understanding the functions of the ICC could lead to innovative perspectives on the modulation of GI motility and introduce new therapeutic paradigms. These insights have the potential to enhance efforts to combat neurointestinal diseases and may lead to interventions that could alleviate or even reverse these conditions.

AB - Neurointestinal diseases result from dysregulated interactions between the nervous system and the gastrointestinal (GI) tract, leading to conditions such as Hirschsprung’s disease and irritable bowel syndrome. These disorders affect many people, significantly diminishing their quality of life and overall health. Central to GI motility are the interstitial cells of Cajal (ICC), which play a key role in muscle contractions and neuromuscular transmission. This review highlights the role of ICC in neurointestinal diseases, revealing their association with various GI ailments. Understanding the functions of the ICC could lead to innovative perspectives on the modulation of GI motility and introduce new therapeutic paradigms. These insights have the potential to enhance efforts to combat neurointestinal diseases and may lead to interventions that could alleviate or even reverse these conditions.

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The Crucial Role of the Interstitial Cells of Cajal in Neurointestinal Diseases

Abstract

Keywords

ASJC Scopus subject areas

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