TY - JOUR
T1 - The cost‐effectiveness of misoprostol for nonsteroidal antiinflammatory drug–associated adverse gastrointestinal events
AU - Gabriel, Sherine E.
AU - Liisa Jaakkimainen, R.
AU - Bombardier, Claire
PY - 1993/4
Y1 - 1993/4
N2 - Objective. To compare, in a Canadian health care setting, the costs and consequences of 3 strategies of misoprostol prophylaxis for osteoarthritis patients: prophylaxis for all patients taking nonsteroidal antiinflammatory drugs (NSAIDs), for no patients taking NSAIDs, and for only elderly patients (age ≥60) taking NSAIDs. Methods. We designed a decision‐analysis model which incorporated costs (estimated with ulcer patient profiles and medical records), review, and probabilities (estimated from a companion metaanalysis, selected literature review, and Ontario Ministry of Health Statistics). Effectiveness was defined as the number of episodes of gastric ulceration requiring hospitalization or outpatient management that were averted by each strategy. Results. On average, prophylaxis cost an additional $650 for every additional gastrointestinal event prevented. Prophylaxis for elderly NSAID users was cost saving if the ulcer complication rate in this group exceeds 1.2%, or if either the charges for outpatient ulcer treatment exceed $2,000, or the 3‐month price of misoprostol is ≤90. Conclusion. Our results demonstrate that, in this setting, misoprostol prophylaxis may be highly cost effective.
AB - Objective. To compare, in a Canadian health care setting, the costs and consequences of 3 strategies of misoprostol prophylaxis for osteoarthritis patients: prophylaxis for all patients taking nonsteroidal antiinflammatory drugs (NSAIDs), for no patients taking NSAIDs, and for only elderly patients (age ≥60) taking NSAIDs. Methods. We designed a decision‐analysis model which incorporated costs (estimated with ulcer patient profiles and medical records), review, and probabilities (estimated from a companion metaanalysis, selected literature review, and Ontario Ministry of Health Statistics). Effectiveness was defined as the number of episodes of gastric ulceration requiring hospitalization or outpatient management that were averted by each strategy. Results. On average, prophylaxis cost an additional $650 for every additional gastrointestinal event prevented. Prophylaxis for elderly NSAID users was cost saving if the ulcer complication rate in this group exceeds 1.2%, or if either the charges for outpatient ulcer treatment exceed $2,000, or the 3‐month price of misoprostol is ≤90. Conclusion. Our results demonstrate that, in this setting, misoprostol prophylaxis may be highly cost effective.
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U2 - 10.1002/art.1780360404
DO - 10.1002/art.1780360404
M3 - Article
C2 - 8457220
AN - SCOPUS:0027509769
SN - 0004-3591
VL - 36
SP - 447
EP - 459
JO - Arthritis & Rheumatism
JF - Arthritis & Rheumatism
IS - 4
ER -