The corticobasal syndrome-Alzheimer's disease conundrum

Research output: Contribution to journalReview articlepeer-review

38 Scopus citations


Corticobasal syndrome (CBS), once thought to be pathognomonic for corticobasal degeneration pathology, is increasingly reported with various underlying pathologies. Alzheimer's disease is one such pathology, also once believed to be unique for its clinical syndrome of dementia of the Alzheimer's type. CBS is believed to result from topography of asymmetric parietofrontal cortical lesion involvement, rather than lesion subtype. However, this topographical pattern is strikingly different to that typically associated with AD for unclear reasons. This article will focus on CBS with underlying AD pathology (CBS-AD), and will review associated clinical, imaging and demographic factors. Predicting AD pathology is of marked interest as disease-modifying therapies loom on the horizon, with biomarkers and imaging research underway. By reviewing the literature for CBS-AD case reports and series and contrasting them with CBS with underlying corticobasal degeneration pathology cases, the article aims to examine factors that may predict AD pathology. How AD pathology may produce this clinical phenotype, rather than the prototype dementia of the Alzheimer's type, will also be reviewed.

Original languageEnglish (US)
Pages (from-to)1569-1578
Number of pages10
JournalExpert review of neurotherapeutics
Issue number11
StatePublished - Nov 2011


  • Alzheimer's disease
  • alien limb
  • apraxia
  • corticobasal degeneration
  • corticobasal syndrome
  • dementia
  • myoclonus
  • rigidity
  • tau
  • voxel-based morphometry

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology
  • Pharmacology (medical)


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