The controversy surrounding the pathogenesis of the multiple sclerosis lesion

F. Claudia, I. Lucchinett, Moses Rodriguez

Research output: Contribution to journalArticlepeer-review

46 Scopus citations


The main issues in multiple sclerosis research revolve around four fundamental questions. (1)What initiates the disease-that is, autoimmune T cells; a virus, or a toxin? (2) Is the inflammatory response primary to the development of demyelination, or is it a secondary response to injury? (3) Is the oligodendrocyte, the myelin-producing cell, the primary target? (4) How can myelin repair be promoted? This review focuses on the controversies revolving around these important questions. Although many investigators believe that T-cell receptors on CD4+ cells interact with myelin antigens to initiate an inflammatory cascade that leads to myelin destruction, others maintain that a viral agent may have a direct or indirect role in the pathogenesis of multiple sclerosis. The concept that the immune system contributes to the tissue destruction in multiple sclerosis is generally accepted; however, the debate about cause versus consequence of the pathologic process remains unresolved, as does the identification of the initial event or focus of the damage. Electron microscopic studies have disclosed evidence of remyelination (albeit often incomplete) in lesions of multiple sclerosis. Enhanced understanding of the factors limiting remyelination could help formulate strategies to promote repair. By innovative experimental design and application of available molecular techniques, the answers to these questions may provide insights on how to prevent or treat multiple sclerosis.

Original languageEnglish (US)
Pages (from-to)665-678
Number of pages14
JournalMayo Clinic proceedings
Issue number7
StatePublished - 1997

ASJC Scopus subject areas

  • General Medicine


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