Abstract
Contrast-enhanced brain MRI is the imaging modality of choice in diagnosis and posttreatment evaluation, but its role is limited in distinguishing recurrent lesions from postoperative changes. 68Ga-DOTATATE is a somatostatin analog PET tracer that has high affinity to meningioma expressing somatostatin receptor. Methods: In this case series review, we describe 8 patients with brain MRI showing suspected recurrent meningioma who underwent focused 68Ga-DOTATATE PET/CT for radiation treatment planning. Results: The combined brain MRI and PET/CT improved the conspicuity of the lesions and aided radiation treatment planning. The time from the initial surgery to PET/CT varied widely, ranging from 1 to 12 y. Three patients underwent PET/CT shortly after the initial surgery (1-3 y) and underwent targeted radiation therapy. Subsequent imaging showed no evidence of recurrence. Four patients had a prolonged time between the PET/CT and the initial surgery (7-12 y), which showed an extensive tumor burden. All 4 patients died shortly after the last PET/CT scan. Conclusion: 68Ga-DOTATATE PET shows a promising complementary role in detection and treatment planning of recurrent meningioma.
Original language | English (US) |
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Pages (from-to) | 348-352 |
Number of pages | 5 |
Journal | Journal of nuclear medicine technology |
Volume | 50 |
Issue number | 4 |
DOIs | |
State | Published - Dec 1 2022 |
Keywords
- DOTATATE
- meningioma
- octreotide
- somatostatin receptor
ASJC Scopus subject areas
- General Medicine