The classification of diabetes by clinical and C-peptide criteria: A prospective population-based study

F. John Service, Robert A. Rizza, Bruce R. Zimmerman, Peter J. Dyck, Peter C. O'Brien, L. Joseph Melton

Research output: Contribution to journalArticlepeer-review

62 Scopus citations


OBJECTIVE - To evaluate both the concordance in the classification of diabetes by clinical and C-peptide criteria and, prospectively, the consistency of the classification by C-peptide. RESEARCH DESIGN AND METHODS - Individuals with diabetes who were enlisted in the prospective epidemiological study of diabetic neuropathy (Rochester Diabetic Neuropathy Study [RDNS]) were classified clinically by National Diabetes Data Group (NDDG) criteria to IDDM and NIDDM at entry to the study. In addition, C- peptide response to 1 mg glucagon was measured at entry for the classification to IDDM (basal C-peptide, <0.17 pmol/ml: increment above basal, <0.07 pmol/ml) and NIDDM (all other responses) and for concordance with the clinical classification made. The consistency of the C-peptide response was assessed every 2 years for up to 8 years. RESULTS - Among 346 individuals with diabetes, 84 were classified as IDDM and 262 as NIDDM by clinical algorithm. Concordance with the C-peptide response occurred in 89% of the patients and remained consistent during 8 years of follow up. Among the 37 patients with discordant clinical and C-peptide classification, those considered clinically to have NIDDM had a consistent IDDM C-peptide response during follow-up, and most of those considered to have IDDM clinically eventually showed an IDDM C-peptide response during follow up. CONCLUSIONS - Clinical criteria for the classification of diabetes are highly correlated with the assessment of insulin secretory, reserve. A small number of individuals considered to have NIDDM clinically or by C-peptide have or develop an IDDM peptide response.

Original languageEnglish (US)
Pages (from-to)198-201
Number of pages4
JournalDiabetes care
Issue number2
StatePublished - Feb 1997

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialized Nursing


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