The Assessment of Endovascular Therapies in Ischemic Stroke: Management, Problems and Future Approaches

Tadeusz J. Popiela, Wirginia Krzyściak, Fabio Pilato, Anna Ligęzka, Beata Bystrowska, Karolina Bukowska-Strakova, Paweł Brzegowy, Karthik Muthusamy, Tamas Kozicz

Research output: Contribution to journalReview articlepeer-review


Ischemic stroke accounts for over 80% of all strokes and is one of the leading causes of mortality and permanent disability worldwide. Intravenous administration of recombinant tissue plasminogen activator (rt-PA) is an approved treatment strategy for acute ischemic stroke of large arteries within 4.5 h of onset, and mechanical thrombectomy can be used for large arteries occlusion up to 24 h after onset. Improving diagnostic work up for acute treatment, reducing onset-to-needle time and urgent radiological access angiographic CT images (angioCT) and Magnetic Resonance Imaging (MRI) are real problems for many healthcare systems, which limits the number of patients with good prognosis in real world compared to the results of randomized controlled trials. The applied endovascular procedures demonstrated high efficacy, but some cellular mechanisms, following reperfusion, are still unknown. Changes in the morphology and function of mitochondria associated with reperfusion and ischemia-reperfusion neuronal death are still understudied research fields. Moreover, future research is needed to elucidate the relationship between continuously refined imaging techniques and the variable structure or physical properties of the clot along with vascular permeability and the pleiotropism of ischemic reperfusion lesions in the penumbra, in order to define targeted preventive procedures promoting long-term health benefits.

Original languageEnglish (US)
Article number1864
JournalJournal of Clinical Medicine
Issue number7
StatePublished - Apr 1 2022


  • clots
  • endovascular therapies
  • ischemic stroke
  • mechanical thrombectomy
  • mitochondria
  • rt-PA
  • thrombolysis

ASJC Scopus subject areas

  • General Medicine


Dive into the research topics of 'The Assessment of Endovascular Therapies in Ischemic Stroke: Management, Problems and Future Approaches'. Together they form a unique fingerprint.

Cite this