TY - JOUR
T1 - The Akt/mTOR and mitogen-activated protein kinase pathways in lung cancer therapy
AU - Papadimitrakopoulou, Vassiliki
AU - Adjei, Alex A.
PY - 2006/9
Y1 - 2006/9
N2 - Aberrant intracellular signaling resulting from mutations and oncogenic activation, as well as gene amplification of critical proteins involved in signal transduction pathways, are key features of lung cancer. Three important intracellular signaling proteins, the mammalian target of rapamycin, protein kinase B, and mitogen-activated protein kinase kinase have emerged as attractive targets for lung cancer therapy. We review current information on the therapeutic manipulation of these targets and describe early clinical data in lung cancer.
AB - Aberrant intracellular signaling resulting from mutations and oncogenic activation, as well as gene amplification of critical proteins involved in signal transduction pathways, are key features of lung cancer. Three important intracellular signaling proteins, the mammalian target of rapamycin, protein kinase B, and mitogen-activated protein kinase kinase have emerged as attractive targets for lung cancer therapy. We review current information on the therapeutic manipulation of these targets and describe early clinical data in lung cancer.
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U2 - 10.1097/01243894-200609000-00031
DO - 10.1097/01243894-200609000-00031
M3 - Review article
C2 - 17409953
AN - SCOPUS:34247850958
SN - 1556-0864
VL - 1
SP - 749
EP - 751
JO - Journal of Thoracic Oncology
JF - Journal of Thoracic Oncology
IS - 7
ER -