Using glass microelectrode technique and whole-cell patch clamp technique, we studied the action and mechanism of endothelin-1 (ET-1) inducing early after depolarizations (EADs) in guinea pig ventricular myocytes. The results suggested that the prolongation of APD50 was induced and EADs was demonstrated with 50 nmol/L ET-1 perfusion. These were resulted from the enhancement of L-Ica influx and a left shift on the steady-state activation curve with dose-dependence.
|Original language||English (US)|
|Journal||Chinese Journal of Cardiology|
|State||Published - 1995|
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