Testicular Choriocarcinoma: a Rare Variant that Requires a Unique Treatment Approach

Matthew James Reilley, Lance C. Pagliaro

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations


Testicular germ cell tumors represent the most common malignancy among young men. While 5-year overall survival and cure for this population is greater than 95 %, choriocarcinoma is an aggressive subtype of this disease with far worse prognosis—5-year survival for choriocarcinoma is less than 80 %. In order to be able to treat these patients appropriately, a provider must recognize characteristic features of choriocarcinoma including elevated human chorionic gonadotropin in a young man with testicular mass; the astute clinician should also know the signs and symptoms of choriocarcinoma syndrome, characterized by bleeding from metastatic sites, which represents a medical emergency and is associated with high morbidity and mortality. Treatment should be directed towards a goal of tumor marker normalization, and patients with refractory disease should be considered for advanced therapies and clinical trials. Choriocarcinoma is a unique and aggressive germ cell malignancy, and these patients require early aggressive treatment to improve their chance of survival.

Original languageEnglish (US)
JournalCurrent oncology reports
Issue number2
StatePublished - 2015


  • Choriocarcinoma
  • Choriocarcinoma syndrome
  • Germ cell malignancy
  • Germ cell tumor
  • Metastatic testicular cancer
  • Testicular cancer

ASJC Scopus subject areas

  • Oncology


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