Ten-year clinical outcomes in patients with intermediate coronary stenosis according to the combined culprit lesion

Yong Kyun Kim, Chae Won Jang, Soon Ho Kwon, Jae Hoon Kim, Amir Lerman, Jang Ho Bae

Research output: Contribution to journalArticlepeer-review


Background: We assessed the long-term clinical outcomes of an intermediate lesion (IL) according to the presence of a combined culprit lesion (CCL). Hypothesis: Long-term clinical outcomes of IL may be affected by the presence of a CCL. Methods: Angiographic findings (n = 1096) and medical chart were reviewed. Patients with IL were divided into two groups: IL without CCL group (n = 383, 64.5%) and IL with CCL group (n = 211, 35.5%). Results: The major adverse cardiovascular events (MACE) in the IL with CCL group were significantly higher than those in the IL without CCL group (death: 12.3% vs. 7.0%, myocardial infarction: 3.3%vs. 0.5%, stroke: 6.6% vs. 2.6%, and revascularization [RVSC]: 25.1% vs. 7.6%) during a mean follow up period of 118.4 ± 5.5 months. IL related RVSC rate in the IL with CCL group was higher than that in the IL without CCL group (5.7% vs. 2.1%, p = 0.020). RVSC rate related to IL in total subjects was lower than that related to stented lesion (3.4% vs. 6.4%). The important predictors of total MACE in total subjects were the presence of CCL, IL percent diameter stenosis, hypertension, history of percutaneous coronary intervention, blood glucose and ejection fraction. The predictors of IL related RVSC were IL percent diameter stenosis and IL located in the right coronary artery. Conclusion: 10-year clinical outcomes of an IL (especially IL without CCL) were better than those of stented lesions. This study suggests that the IL can be safely followed up in sites that do not have ability to assess functional study.

Original languageEnglish (US)
Pages (from-to)1161-1168
Number of pages8
JournalClinical Cardiology
Issue number8
StatePublished - Aug 2021


  • coronary artery stenosis
  • intermediate coronary lesion
  • prognosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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