Temporal pole blurring in temporal lobe epilepsy revealed by 3D Edge-Enhancing Gradient Echo MRI

Lela Okromelidze, Vivek Gupta, Ayushi Jain, Neethu Gopal, Anteneh M. Feyissa, William O. Tatum, Alfredo Quiñones-Hinojosa, Sanjeet S. Grewal, Erik H. Middlebrooks

Research output: Contribution to journalArticlepeer-review


While abnormalities of the hippocampus have been well characterized in temporal lobe epilepsy, various additional temporal lobe abnormalities have also been described. One poorly understood entity, the so-called temporal pole blurring (TPB), is one of the more frequently described neocortical abnormalities in TLE and is thought to represent dysmyelination and axonal loss due to chronic electrical perturbations in early age-onset temporal lobe epilepsy. In this study, we describe the first reported cases of TPB diagnosed by a recently described MRI sequence known as 3D Edge-Enhancing Gradient Echo (3D-EDGE), which has an effective “myelin weighting” making it exquisitely sensitive to this temporal pole dysmyelination. The value of detection of TPB lies in lateralizing seizure onset, as well as predicting a lower baseline neuropsychological performance compared to temporal lobe epilepsy without TPB. Additionally, it is critical to not mistake TPB for alternative diagnoses, such as focal cortical dysplasia or neoplasm.

Original languageEnglish (US)
JournalNeuroradiology Journal
StateAccepted/In press - 2022


  • epilepsy
  • mesial temporal
  • sclerosis
  • temporal lobe epilepsy
  • temporal pole blurring

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology


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