Temporal metabolic response to mRNA COVID-19 vaccinations in oncology patients

Pooja Advani; Saranya Chumsri; Tanmayi Pai; Zhuo Li; Akash Sharma; Ephraim Parent

doi:10.1007/s12149-021-01675-8

Temporal metabolic response to mRNA COVID-19 vaccinations in oncology patients

Pooja Advani, Saranya Chumsri, Tanmayi Pai, Zhuo Li, Akash Sharma, Ephraim Parent

Hematology / Oncology / Cancer Center / Breast Clinic

Research output: Contribution to journal › Article › peer-review

Abstract

Background: mRNA COVID-19 vaccines are known to provide an immune response seen on FDG PET studies. However, the time course of this metabolic response is unknown. We here present a temporal metabolic response to mRNA COVID-19 vaccination in oncology patients undergoing standard of care FDG PET. Methods: 262 oncology patients undergoing standard of care FDG PET were included in the analysis. 231 patients had at least one dose of mRNA COVID-19 vaccine while 31 patients had not been vaccinated. The SUVmax of the lymph nodes ipsilateral to the vaccination was compared to the contralateral to obtain an absolute change in SUVmax (ΔSUVmax). Results: ΔSUVmax was more significant at shorter times between FDG PET imaging and COVID-19 mRNA vaccination, with a median ΔSUVmax of 2.6 (0–7 days), 0.8 (8–14 days), and 0.3 (> 14 days), respectively. Conclusion: Consideration should be given to performing FDG PET at least 2 weeks after the COVID-19 vaccine.

Original language	English (US)
Pages (from-to)	1264-1269
Number of pages	6
Journal	Annals of Nuclear Medicine
Volume	35
Issue number	11
DOIs	https://doi.org/10.1007/s12149-021-01675-8
State	Published - Nov 2021

Keywords

COVID-19
FDG
Vaccine

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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10.1007/s12149-021-01675-8

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title = "Temporal metabolic response to mRNA COVID-19 vaccinations in oncology patients",

abstract = "Background: mRNA COVID-19 vaccines are known to provide an immune response seen on FDG PET studies. However, the time course of this metabolic response is unknown. We here present a temporal metabolic response to mRNA COVID-19 vaccination in oncology patients undergoing standard of care FDG PET. Methods: 262 oncology patients undergoing standard of care FDG PET were included in the analysis. 231 patients had at least one dose of mRNA COVID-19 vaccine while 31 patients had not been vaccinated. The SUVmax of the lymph nodes ipsilateral to the vaccination was compared to the contralateral to obtain an absolute change in SUVmax (ΔSUVmax). Results: ΔSUVmax was more significant at shorter times between FDG PET imaging and COVID-19 mRNA vaccination, with a median ΔSUVmax of 2.6 (0–7 days), 0.8 (8–14 days), and 0.3 (> 14 days), respectively. Conclusion: Consideration should be given to performing FDG PET at least 2 weeks after the COVID-19 vaccine.",

keywords = "COVID-19, FDG, Vaccine",

author = "Pooja Advani and Saranya Chumsri and Tanmayi Pai and Zhuo Li and Akash Sharma and Ephraim Parent",

note = "Publisher Copyright: {\textcopyright} 2021, The Author(s).",

year = "2021",

month = nov,

doi = "10.1007/s12149-021-01675-8",

language = "English (US)",

volume = "35",

pages = "1264--1269",

journal = "Annals of Nuclear Medicine",

issn = "0914-7187",

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T1 - Temporal metabolic response to mRNA COVID-19 vaccinations in oncology patients

AU - Advani, Pooja

AU - Chumsri, Saranya

AU - Pai, Tanmayi

AU - Li, Zhuo

AU - Sharma, Akash

AU - Parent, Ephraim

PY - 2021/11

Y1 - 2021/11

N2 - Background: mRNA COVID-19 vaccines are known to provide an immune response seen on FDG PET studies. However, the time course of this metabolic response is unknown. We here present a temporal metabolic response to mRNA COVID-19 vaccination in oncology patients undergoing standard of care FDG PET. Methods: 262 oncology patients undergoing standard of care FDG PET were included in the analysis. 231 patients had at least one dose of mRNA COVID-19 vaccine while 31 patients had not been vaccinated. The SUVmax of the lymph nodes ipsilateral to the vaccination was compared to the contralateral to obtain an absolute change in SUVmax (ΔSUVmax). Results: ΔSUVmax was more significant at shorter times between FDG PET imaging and COVID-19 mRNA vaccination, with a median ΔSUVmax of 2.6 (0–7 days), 0.8 (8–14 days), and 0.3 (> 14 days), respectively. Conclusion: Consideration should be given to performing FDG PET at least 2 weeks after the COVID-19 vaccine.

AB - Background: mRNA COVID-19 vaccines are known to provide an immune response seen on FDG PET studies. However, the time course of this metabolic response is unknown. We here present a temporal metabolic response to mRNA COVID-19 vaccination in oncology patients undergoing standard of care FDG PET. Methods: 262 oncology patients undergoing standard of care FDG PET were included in the analysis. 231 patients had at least one dose of mRNA COVID-19 vaccine while 31 patients had not been vaccinated. The SUVmax of the lymph nodes ipsilateral to the vaccination was compared to the contralateral to obtain an absolute change in SUVmax (ΔSUVmax). Results: ΔSUVmax was more significant at shorter times between FDG PET imaging and COVID-19 mRNA vaccination, with a median ΔSUVmax of 2.6 (0–7 days), 0.8 (8–14 days), and 0.3 (> 14 days), respectively. Conclusion: Consideration should be given to performing FDG PET at least 2 weeks after the COVID-19 vaccine.

KW - COVID-19

KW - FDG

KW - Vaccine

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JO - Annals of Nuclear Medicine

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IS - 11

ER -

Temporal metabolic response to mRNA COVID-19 vaccinations in oncology patients

Abstract

Keywords

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