Telomere dysfunction in ageing and age-related diseases

Francesca Rossiello, Diana Jurk, João F. Passos, Fabrizio d’Adda di Fagagna

Research output: Contribution to journalReview articlepeer-review


Ageing organisms accumulate senescent cells that are thought to contribute to body dysfunction. Telomere shortening and damage are recognized causes of cellular senescence and ageing. Several human conditions associated with normal ageing are precipitated by accelerated telomere dysfunction. Here, we systematize a large body of evidence and propose a coherent perspective to recognize the broad contribution of telomeric dysfunction to human pathologies.

Original languageEnglish (US)
Pages (from-to)135-147
Number of pages13
JournalNature Cell Biology
Issue number2
StatePublished - Feb 2022

ASJC Scopus subject areas

  • Cell Biology


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