Targeting pancreatic cancer with magneto-fluorescent theranostic gold nanoshells

Wenxue Chen, Ciceron Ayala-Orozco, Nrusingh C. Biswal, Carlos Perez-Torres, Marc Bartels, Rizia Bardhan, Gary Stinnet, Xian De Liu, Baoan Ji, Amit Deorukhkar, Lisa V. Brown, Sushovan Guha, Robia G. Pautler, Sunil Krishnan, Naomi J. Halas, Amit Joshi

Research output: Contribution to journalArticlepeer-review

52 Scopus citations


Aim: We report a magneto-fluorescent theranostic nanocomplex targeted to neutrophil gelatinase-associated lipocalin (NGAL) for imaging and therapy of pancreatic cancer. Materials & methods: Gold nanoshells resonant at 810 nm were encapsulated in silica epilayers doped with iron oxide and the near-infrared (NIR) dye indocyanine green, resulting in theranostic gold nanoshells (TGNS), which were subsequently conjugated with antibodies targeting NGAL in AsPC-1-derived xenografts in nude mice. Results: Anti-NGAL-conjugated TGNS specifically targeted pancreatic cancer cells in vitro and in vivo providing contrast for both NIR fluorescence and T2-weighted MRI with higher tumor contrast than can be obtained using long-circulating, but nontargeted, PEGylated nanoparticles. The nanocomplexes also enabled highly specific cancer cell death via NIR photothermal therapy in vitro. Conclusion: TGNS with embedded NIR and magnetic resonance contrasts can be specifically targeted to pancreatic cancer cells with expression of early disease marker NGAL, and enable molecularly targeted imaging and photothermal therapy.

Original languageEnglish (US)
Pages (from-to)1209-1222
Number of pages14
Issue number8
StatePublished - Jun 2014


  • MRI
  • nanoshells
  • noninvasive imaging
  • optical imaging
  • pancreatic cancer
  • photothermal

ASJC Scopus subject areas

  • Bioengineering
  • Development
  • Biomedical Engineering
  • General Materials Science
  • Medicine (miscellaneous)


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