TY - JOUR
T1 - Targeting ACE2-BRD4 crosstalk in colorectal cancer and the deregulation of DNA repair and apoptosis
AU - Zhang, Shilan
AU - Kapoor, Sabeeta
AU - Tripathi, Chakrapani
AU - Perez, Jorge Tovar
AU - Mohan, Nivedhitha
AU - Dashwood, Wan Mohaiza
AU - Zhang, Ke
AU - Rajendran, Praveen
AU - Dashwood, Roderick
N1 - Publisher Copyright:
© 2023, The Author(s).
PY - 2023/12
Y1 - 2023/12
N2 - ACE2 overexpression in colorectal cancer patients might increase susceptibility to SARS-CoV-2 infection. We report that knockdown, forced overexpression, and pharmacologic inhibition in human colon cancer cells targeted ACE2-BRD4 crosstalk to mediate marked changes in DNA damage/repair and apoptosis. In colorectal cancer patients for whom high ACE2 plus high BRD4 expression is predictive of poor survival, pan-BET inhibition would need to consider proviral/antiviral actions of different BET proteins during SARS-CoV-2 infection.
AB - ACE2 overexpression in colorectal cancer patients might increase susceptibility to SARS-CoV-2 infection. We report that knockdown, forced overexpression, and pharmacologic inhibition in human colon cancer cells targeted ACE2-BRD4 crosstalk to mediate marked changes in DNA damage/repair and apoptosis. In colorectal cancer patients for whom high ACE2 plus high BRD4 expression is predictive of poor survival, pan-BET inhibition would need to consider proviral/antiviral actions of different BET proteins during SARS-CoV-2 infection.
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UR - http://www.scopus.com/inward/citedby.url?scp=85148362016&partnerID=8YFLogxK
U2 - 10.1038/s41698-023-00361-4
DO - 10.1038/s41698-023-00361-4
M3 - Article
AN - SCOPUS:85148362016
SN - 2397-768X
VL - 7
JO - npj Precision Oncology
JF - npj Precision Oncology
IS - 1
M1 - 20
ER -