Abstract
Cox proportional hazards regressions with time-dependent covariates were used to determine the effect of continuous, long-term, open-label tacrine hydrochloride (Cognex®) treatment on nursing home placement in patients with Alzheimer's disease (AD). The results were compared with those obtained using logistic regression analyses, life table survival plots, and Kaplan-Meier estimates. Patients with probable AD (NINCDS criteria) initially randomized in a 30-week double-blind, placebo-controlled, parallel-group, high-dose study of tactrine could continue on long-term, open-label treatment at doses up to 160 mg/day. The population of interest consisted of patients who remained on tacrine or were off tacrine for only a short period of time (1- 60 days) prior to an event. Using last tacrine dose, the Cox proportional hazards regression approach with time-dependent covariates demonstrated there was a dose-response trend favoring higher doses (risk ratio = 1.7, p = 0.056) and a statistically significant difference favoring medium and higher doses combined (risk ratio = 1.8, p = 0.014).
Original language | English (US) |
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Pages (from-to) | 729-735 |
Number of pages | 7 |
Journal | Drug Information Journal |
Volume | 32 |
Issue number | 3 |
DOIs | |
State | Published - 1998 |
Keywords
- Cox proportional hazards
- Nursing home placement
- Survival analysis
- Tacrine hydrochloride
- Time-dependent covariates
ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health
- Pharmacology (medical)
- Drug guides
- Pharmacology (nursing)