TY - JOUR
T1 - Tackling the phosphoproteome
T2 - Tools and strategies
AU - Kalume, Dario E.
AU - Molina, Henrik
AU - Pandey, Akhilesh
PY - 2003/2
Y1 - 2003/2
N2 - Characterization of post-translational modifications in proteins is one of the major tasks that is to be accomplished in the post-genomic era. Phosphorylation is a key reversible modification that regulates enzymatic activity, subcellular localization, complex formation and degradation of proteins. Rapid advances in mass spectrometry instrumentation coupled to the development of analytical methods over the past several years now allow us to investigate the phosphoproteome on a global scale.
AB - Characterization of post-translational modifications in proteins is one of the major tasks that is to be accomplished in the post-genomic era. Phosphorylation is a key reversible modification that regulates enzymatic activity, subcellular localization, complex formation and degradation of proteins. Rapid advances in mass spectrometry instrumentation coupled to the development of analytical methods over the past several years now allow us to investigate the phosphoproteome on a global scale.
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U2 - 10.1016/S1367-5931(02)00009-1
DO - 10.1016/S1367-5931(02)00009-1
M3 - Review article
C2 - 12547428
AN - SCOPUS:0037305895
SN - 1367-5931
VL - 7
SP - 64
EP - 69
JO - Current Opinion in Chemical Biology
JF - Current Opinion in Chemical Biology
IS - 1
ER -