T Cells and Vascular Inflammation

Research output: Chapter in Book/Report/Conference proceedingChapter


T cells are critical regulatory and effector cells in vascular inflammation. T-cell activation as well as T-cell tolerance is the end result of a complex integration of signals through the T-cell receptor and co-stimulatory molecules as well as signals from regulatory T cells. Naïve CD4 T cells are pluripotent and can differentiate into an increasing number of effector lineages such as Th1, Th2, Th9, Th17 and follicular helper T cells or into regulatory T cells (Treg). Lineage commitment is not irreversible and some plasticity persists in differentiated T cells, in particular Tregs can differentiate into Th17. Disease patterns in vasculitides is influenced by the effector type as well as the stage of T-cell differentiation. Accumulation of end-differentiated T-effector cells is frequently associated with vascular inflammation. Molecular characterization of the signaling events in T-cell activation, T-cell tolerance and T-cell differentiation has been instrumental in identifying targets for developing T-cell-directed therapies. Understanding how T-cell effector functions contribute to different vasculitides provides a framework to decide which and how these treatments should be explored.

Original languageEnglish (US)
Title of host publicationInflammatory Diseases of Blood Vessels
Subtitle of host publicationSecond Edition
Number of pages11
ISBN (Print)9781444338225
StatePublished - May 3 2012


  • Regulatory T cell
  • T cell
  • T-cell differentiation
  • Th1
  • Th17
  • Th2
  • Vasculitis

ASJC Scopus subject areas

  • General Medicine


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