T-cell/histiocyte-rich large B-cell lymphoma presenting as a primary central nervous system lymphoma

Pooja Advani, Jason Starr, Abhisek Swaika, Liuyan Jiang, Yushi Qiu, Zhimin Li, Han W. Tun

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Primary central nervous system (PCNSL) lymphoma is an aggressive extranodal non- Hodgkin lymphoma, and most cases are classified as diffuse large B-cell lymphoma (DLBCL) by histology. T-cell/histiocyte-rich large B-cell lymphoma (TCRLBCL) represents a distinct subtype of diffuse large B-cell lymphoma and is characterized by the presence of scattered large neoplastic B-cells in a background of abundant T-cells and histiocytes. This is in contrast to the dense perivascular cuffing of neoplastic B-cells in classic DLBCL. T-cell/histiocyte- rich large B-cell lymphoma should be considered in PCNSL cases in which neoplastic B-cells are sparse and scattered. Immunohistochemistry will help identify the B-cells and surrounding infiltrate rich in Tlymphocytes and histiocytes. Future studies exploring the biology of TCRLBCL and the crosstalk between the neoplastic cells and the surrounding inflammatory infiltrate may provide exciting prospects for future therapies for TCRLBCL.

Original languageEnglish (US)
Article number6084
Pages (from-to)160-162
Number of pages3
JournalRare Tumors
Issue number4
StatePublished - Dec 29 2015


  • Central nervous system
  • Diffuse large B-cell lymphoma
  • Osteopontin
  • T-cell/histiocyterich large B-cell lymphoma

ASJC Scopus subject areas

  • Histology
  • Oncology


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