T-cell lymphoblastic leukemia/lymphoma presenting in a recurrent thymoma.

W. R. Macon, T. H. Rynalski, S. H. Swerdlow, J. B. Cousar

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


A lymphoblastic malignancy presented as the lymphoid component of a recurrent invasive lymphocyte-rich thymoma that had been previously resected and treated with chemotherapy. This high grade lymphoid neoplasm concurrently involved mediastinal nodes and subsequently disseminated to pleural fluid and peripheral blood. Lymphocytes with convoluted nuclei demonstrated a T-lymphoblastic phenotype (UCHL1+, Leu-22+, TdT+) by immunohistochemical studies. T-cell lymphoblastic leukemia/lymphomas in this clinical setting have not been reported, and this case suggests that neoplastic transformation of lymphocytes may occur in longstanding refractory thymomas.

Original languageEnglish (US)
Pages (from-to)524-528
Number of pages5
JournalModern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Issue number4
StatePublished - Jul 1991

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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