Systemic Mastocytosis. Disease Overview, Pathogenesis, and Treatment

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15 Scopus citations


The clinical presentation of mastocytosis is diverse, and patients may not fit the classical description. Diagnosis requires a bone marrow examination, including immunohistochemical stains for mast cell tryptase or CD117. The treatment of adult systemic mastocytosis is highly individualized. This article presents an overview of systemic mastocytosis and describes its pathogenesis and treatment.

Original languageEnglish (US)
Pages (from-to)1117-1128
Number of pages12
JournalHematology/Oncology Clinics of North America
Issue number5
StatePublished - Oct 2012


  • KITD816V
  • Mast cell disease
  • Myeloproliferative neoplasm

ASJC Scopus subject areas

  • Hematology
  • Oncology


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