Systemic amyloidosis presenting with angina pectoris

Jassim Al Suwaidi, James L. Velianou, Morie A. Gertz, Richard O. Cannon, Stuart T. Higano, David R. Holmes, Amir Lerman

Research output: Contribution to journalArticlepeer-review

66 Scopus citations


Background: Manifestations of cardiac amyloidosis may include congestive heart failure and sudden cardiac death. Although vascular involvement in patients with amyloidosis is common, systemic amyloidosis presenting with angina is rare. Objectives: To report on patients with systemic amyloidosis presenting with angina pectoris. Design: Case series. Setting: Academic medical center. Patients: Five patients who presented with angina pectoris and normal coronary angiogram as the initial manifestation of systemic amyloidosis. Measurements: Endothelial-dependent and endothelial-independent coronary flow reserve. Results: All patients had coronary flow reserve abnormalities and subsequently developed congestive heart failure and systemic manifestations of amyloidosis. Histologic evaluation revealed amyloid deposition in the intramyocardial coronary vessels. Conclusions: Cardiac amyloidosis can present as angina pectoris associated with coronary flow reserve abnormalities despite normal coronary angiograms. This finding may have major therapeutic and prognostic implications in this patient population.

Original languageEnglish (US)
Pages (from-to)838-841
Number of pages4
JournalAnnals of internal medicine
Issue number11
StatePublished - Dec 7 1999

ASJC Scopus subject areas

  • Internal Medicine


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