Synucleinopathy pathology and REM sleep behavior disorder plus dementia or parkinsonism

B. F. Boeve, M. H. Silber, J. E. Parisi, D. W. Dickson, T. J. Ferman, E. E. Benarroch, A. M. Schmeichel, G. E. Smith, R. C. Petersen, J. E. Ahlskog, J. Y. Matsumoto, D. S. Knopman, C. H. Schenck, M. W. Mahowald

Research output: Contribution to journalArticlepeer-review

320 Scopus citations


Objective: To determine if synucleinopathy pathology is related to REM sleep behavior disorder (RBD) plus dementia or parkinsonism. Methods: The clinical and neuropathologic findings were analyzed on all autopsied cases evaluated at Mayo Clinic Rochester from January 1990 to April 2002 who were diagnosed with RBD and a neurodegenerative disorder. Ubiquitin and/or α-synuclein immunocytochemistry was used in all cases. The clinical and neuropathologic diagnoses were based on published criteria. Results: Fifteen cases were identified (14 men). All had clear histories of dream enactment behavior, and 10 had RBD confirmed by polysomnography. RBD preceded dementia or parkinsonism in 10 (66.7%) patients by a median of 10 (range 2 to 29) years. The clinical diagnoses included dementia with Lewy bodies (DLB) (n = 6); multiple-system atrophy (MSA) (n = 2); combined DLB, AD, and vascular dementia (n = 1); dementia (n = 1); dementia with parkinsonism (n = 1); PD (n = 1); PD with dementia (n = 1); dementia/parkinsonism/motor neuron disease (n = 1); and AD/Binswanger's disease (n = 1). The neuropathologic diagnoses were Lewy body disease (LBD) in 12 (neocortical in 11 and limbic in 1) and MSA in 3. Three also had argyrophilic grain pathology. In the LBD cases, concomitant AD pathology was present in six (one also with Binswanger's pathology, and one also with multiple subcortical infarcts). Conclusion: In the setting of degenerative dementia or parkinsonism, RBD often reflects an underlying synucleinopathy.

Original languageEnglish (US)
Pages (from-to)40-45
Number of pages6
Issue number1
StatePublished - Jul 8 2003

ASJC Scopus subject areas

  • Clinical Neurology


Dive into the research topics of 'Synucleinopathy pathology and REM sleep behavior disorder plus dementia or parkinsonism'. Together they form a unique fingerprint.

Cite this