Synthesis of racemic [2′‐13C]tryptophan

B. R. Branchini, F. G. Prendergast, G. A. Spencer, J. D. Hugdahl, B. D. Ray, M. D. Kemple

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


[2‐13C] Indole was synthesized in 39% yield by a three‐step procedure starting with K13CN. The labeled indole was converted to D,L[2′‐13C] tryptophan in three subsequent steps and the overall yield from K13CN was 13.5%. Proton and 13C‐NMR, and GC/mass spectral analyses confirmed the position and extent of 13C incorporation.

Original languageEnglish (US)
Pages (from-to)637-643
Number of pages7
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Issue number6
StatePublished - Jun 1987


  • D, L‐[2′‐C]tryptophan
  • [2‐C] indole
  • indole synthesis
  • tryptophan synthesis

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Radiology Nuclear Medicine and imaging
  • Drug Discovery
  • Spectroscopy
  • Organic Chemistry


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