Synthesis and characterization of pH/temperature-sensitive hydrogels based on chitosan derivative

Akhilesh Pandey, Ippeita Dan, Troels Z. Kristiansen, Norinobu M. Watanabe, Jesper Voldby, Eriko Kajikawa, Roya Khosravi-Far, Blagoy Blagoev, Matthias Mann

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


A series of pH/temperature-sensitive hydrogels composed of maleilated chitosan (MC) and N-isopropylacrylamide (NIPAAm) were prepared and characterized with respect to their swelling behaviors, change of lower critical solution temperature (LCST). These hydrogels showed broad pH-sensitivities below 32 °C, but above that temperature exhibited sharp pH-dependent phase transition behaviors which depended on the content of MC in the hydrogels. The change of ratio of NIPAAm to MC in weight did not affect LCST significantly, while it affected equilibrium water content (EWC) at high pH region. The hydrogels also exhibited a typical of reversibility depending on temperature and pH.

Original languageEnglish (US)
Pages (from-to)451-456
Number of pages6
JournalPolymer Bulletin
Issue number5
StatePublished - Jan 1 2002

ASJC Scopus subject areas

  • Chemistry(all)
  • Condensed Matter Physics
  • Polymers and Plastics
  • Materials Chemistry


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