Abstract
We synthesized 3β-thiovitamin D3 from 7-dehydrocholesterol and tested its biological activity and protein binding properties. The thiovitamin was found to be a weak vitamin D agonist at high doses in vivo. It was poorly bound by both vitamin D-binding protein as well as by the intestinal cytosol receptor for 1,25-dihydroxyvitamin D. It did not increase the synthesis of calcium binding protein in the chick embryonic duodenum and did not block the activity of 1,25-dihydroxyvitamin D3 in this system We conclude that 3β -thiovitamin D3 is a weak vitamin D agonist in vivo with no agonist activity or antagonist activity to 1,25-dihydroxyvitamin D3 in the chick embryonic duodenum.
Original language | English (US) |
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Pages (from-to) | 81-85 |
Number of pages | 5 |
Journal | Journal of Steroid Biochemistry |
Volume | 23 |
Issue number | 1 |
DOIs | |
State | Published - 1985 |
ASJC Scopus subject areas
- Biochemistry
- Endocrinology