Symptom control trials: A 20-year experience

Charles L. Loprinzi, Debra L. Barton, Aminah Jatoi, Jeff Sloan, Jim Martenson, David Steensma, Ravi Rao, Paul Novotny, Amit Sood, Axel Grothey, Lori Minasian, Harold Windschitl

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations


Symptoms related to cancer and/or cancer therapy are a prominent consideration in cancer patients; multiple options have been proposed to alleviate these problems. The US National Cancer Institute (NCI) Community Clinical Oncology Program (CCOP) has mandated that CCOP participant institutions be involved with cancer control trials in addition to cancer treatment trials. Through such efforts, scientifically sound symptom control clinical trials are being conducted to determine the effectiveness of promising agents. In this article, the authors provide an update of clinical trial outcomes regarding 13 symptom and symptom complexes related to cancer and/or cancer therapy, emphasizing that publication of both positive and negative study results is important to separate what works from what does not.

Original languageEnglish (US)
Pages (from-to)119-125+128
JournalJournal of Supportive Oncology
Issue number3
StatePublished - Mar 2007

ASJC Scopus subject areas

  • Oncology
  • Pharmacology (medical)


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