Sympathetic neural mechanisms in human hypertension.

V. K. Somers, E. A. Anderson, A. L. Mark

Research output: Contribution to journalReview articlepeer-review

26 Scopus citations


This review discusses the role of the sympathetic nervous system in the pathogenesis and maintenance of human hypertension. Three points are emphasized: first, there are mechanisms by which the sympathetic nervous system can contribute to the long-term regulation of vascular resistance and arterial pressure in addition to the moment-to-moment regulation of arterial pressure; second, the microneurographic method for direct intraneural recording of sympathetic nerve activity in humans has provided mounting evidence for increased sympathetic neural activity in human essential and renovascular hypertension; and third, there are both peripheral reflex and humoral mechanisms that may contribute to sympathetic overactivity in human hypertension.

Original languageEnglish (US)
Pages (from-to)96-105
Number of pages10
JournalCurrent opinion in nephrology and hypertension
Issue number1
StatePublished - Jan 1993

ASJC Scopus subject areas

  • Internal Medicine
  • Nephrology


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