Sympathetic-Nerve Activity during Sleep

Martin Terplan, Stanley Kalsner, C. J.M. Cockx, Virend K. Somers, Mark E. Dyken, Francois M. Abboud

Research output: Contribution to journalLetterpeer-review

1 Scopus citations


To the Editor: Somers et al. (Feb. 4 issue)1 found that rapid-eye-movement (REM) sleep is associated with profound sympathetic activation in normal subjects. Because sleep cycles change with aging, the hemodynamic and sympathetic changes found during REM sleep in these subjects, whose mean age was 25 years, cannot be extrapolated to explain ischemic events that occur in much older patients. If such sleep-related changes were also found in older people, this might help clarify the higher-than-expected incidence of myocardial infarction and stroke in the morning hours. There is, however, a more likely explanation for this phenomenon. The ischemia may have…

Original languageEnglish (US)
Pages (from-to)1850-1851
Number of pages2
JournalNew England Journal of Medicine
Issue number25
StatePublished - Jun 24 1993

ASJC Scopus subject areas

  • General Medicine


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