Survivin DNA vaccine generated specific antitumor effects in pancreatic carcinoma and lymphoma mouse models

Kuichun Zhu; Hong Qin; Soung Chul Cha; Sattva S. Neelapu; Willem Overwijk; Gregory A. Lizee; James L. Abbruzzese; Patrick Hwu; Laszlo Radvanyi; Larry W. Kwak; David Z. Chang

doi:10.1016/j.vaccine.2007.08.050

Survivin DNA vaccine generated specific antitumor effects in pancreatic carcinoma and lymphoma mouse models

Kuichun Zhu, Hong Qin, Soung Chul Cha, Sattva S. Neelapu, Willem Overwijk, Gregory A. Lizee, James L. Abbruzzese, Patrick Hwu, Laszlo Radvanyi, Larry W. Kwak, David Z. Chang

Hematology / Oncology / Cancer Center / Breast Clinic

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

We investigated the antitumor effect of survivin DNA vaccine in murine pancreatic and lymphoma models, and if xenogenic survivin can generate stronger immune response. We found that mice vaccinated with either human or mouse survivin DNA have significantly slower tumor growth and longer survival than those vaccinated with vector DNA. There was no significant difference between groups that received human and mouse survivin DNA. Lymphocyte infiltration was greater in tumors of mice immunized with survivin DNA than in tumors of control mice. We conclude that survivin DNA vaccine generated specific antitumor effects with increased lymphocyte infiltration at the tumor sites.

Original language	English (US)
Pages (from-to)	7955-7961
Number of pages	7
Journal	Vaccine
Volume	25
Issue number	46
DOIs	https://doi.org/10.1016/j.vaccine.2007.08.050
State	Published - Nov 14 2007

Keywords

DNA vaccine
Pancreatic carcinoma
Survivin

ASJC Scopus subject areas

Molecular Medicine
General Immunology and Microbiology
General Veterinary
Public Health, Environmental and Occupational Health
Infectious Diseases

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10.1016/j.vaccine.2007.08.050

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title = "Survivin DNA vaccine generated specific antitumor effects in pancreatic carcinoma and lymphoma mouse models",

abstract = "We investigated the antitumor effect of survivin DNA vaccine in murine pancreatic and lymphoma models, and if xenogenic survivin can generate stronger immune response. We found that mice vaccinated with either human or mouse survivin DNA have significantly slower tumor growth and longer survival than those vaccinated with vector DNA. There was no significant difference between groups that received human and mouse survivin DNA. Lymphocyte infiltration was greater in tumors of mice immunized with survivin DNA than in tumors of control mice. We conclude that survivin DNA vaccine generated specific antitumor effects with increased lymphocyte infiltration at the tumor sites.",

keywords = "DNA vaccine, Pancreatic carcinoma, Survivin",

author = "Kuichun Zhu and Hong Qin and Cha, {Soung Chul} and Neelapu, {Sattva S.} and Willem Overwijk and Lizee, {Gregory A.} and Abbruzzese, {James L.} and Patrick Hwu and Laszlo Radvanyi and Kwak, {Larry W.} and Chang, {David Z.}",

note = "Funding Information: This study was supported in part by the Topfer Fund for Pancreatic Cancer Research (K.Z.) and a fellowship from the Lymphoma Research Foundation (H.Q.).",

year = "2007",

month = nov,

day = "14",

doi = "10.1016/j.vaccine.2007.08.050",

language = "English (US)",

volume = "25",

pages = "7955--7961",

journal = "Vaccine",

issn = "0264-410X",

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number = "46",

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TY - JOUR

T1 - Survivin DNA vaccine generated specific antitumor effects in pancreatic carcinoma and lymphoma mouse models

AU - Zhu, Kuichun

AU - Qin, Hong

AU - Cha, Soung Chul

AU - Neelapu, Sattva S.

AU - Overwijk, Willem

AU - Lizee, Gregory A.

AU - Abbruzzese, James L.

AU - Hwu, Patrick

AU - Radvanyi, Laszlo

AU - Kwak, Larry W.

AU - Chang, David Z.

N1 - Funding Information: This study was supported in part by the Topfer Fund for Pancreatic Cancer Research (K.Z.) and a fellowship from the Lymphoma Research Foundation (H.Q.).

PY - 2007/11/14

Y1 - 2007/11/14

N2 - We investigated the antitumor effect of survivin DNA vaccine in murine pancreatic and lymphoma models, and if xenogenic survivin can generate stronger immune response. We found that mice vaccinated with either human or mouse survivin DNA have significantly slower tumor growth and longer survival than those vaccinated with vector DNA. There was no significant difference between groups that received human and mouse survivin DNA. Lymphocyte infiltration was greater in tumors of mice immunized with survivin DNA than in tumors of control mice. We conclude that survivin DNA vaccine generated specific antitumor effects with increased lymphocyte infiltration at the tumor sites.

AB - We investigated the antitumor effect of survivin DNA vaccine in murine pancreatic and lymphoma models, and if xenogenic survivin can generate stronger immune response. We found that mice vaccinated with either human or mouse survivin DNA have significantly slower tumor growth and longer survival than those vaccinated with vector DNA. There was no significant difference between groups that received human and mouse survivin DNA. Lymphocyte infiltration was greater in tumors of mice immunized with survivin DNA than in tumors of control mice. We conclude that survivin DNA vaccine generated specific antitumor effects with increased lymphocyte infiltration at the tumor sites.

KW - DNA vaccine

KW - Pancreatic carcinoma

KW - Survivin

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AN - SCOPUS:35448989825

SN - 0264-410X

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SP - 7955

EP - 7961

JO - Vaccine

JF - Vaccine

IS - 46

ER -

Survivin DNA vaccine generated specific antitumor effects in pancreatic carcinoma and lymphoma mouse models

Abstract

Keywords

ASJC Scopus subject areas

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