Surgical risk reduction: Prophylactic salpingo-oophorectomy and prophylactic mastectomy

Sean C. Dowdy, Michael Stefanek, Lynn C. Hartmann

Research output: Contribution to journalArticlepeer-review

44 Scopus citations


Investigators have used retrospective and prospective study designs to provide much needed data on the extent of risk reduction after prophylactic oophorectomy and mastectomy in women at increased risk for breast and ovarian cancer. In this publication we identify those women who may wish to consider prophylactic surgery, review data demonstrating the efficacy of prophylactic surgery, and discuss potential surgical complications. We also present data about the frequency of use and psychosocial impact of prophylactic surgery in this typically young group of women. Finally, we provide general treatment guidelines for the practicing clinician.

Original languageEnglish (US)
Pages (from-to)1113-1123
Number of pages11
JournalAmerican journal of obstetrics and gynecology
Issue number4
StatePublished - Oct 2004


  • Breast cancer
  • Mastectomy
  • Oophorectomy
  • Ovarian cancer
  • Prophylactic

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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