Surgical pathology of granulomatous interstitial pneumonia

Oi Yee Cheung, J. R. Muhm, R. A. Helmers, Marie Christine Aubry, Henry D. Tazelaar, Andras Khoor, Kevin O. Leslie, Thomas V. Colby

Research output: Contribution to journalReview articlepeer-review

46 Scopus citations


A granulomatous interstitial pneumonia is a form of diffuse lung disease in which granulomas are a component of the histologic findings. The differential diagnosis is quite broad, but most cases represent examples of either sarcoidosis, diffuse granulomatous infections, or hypersensitivity pneumonitis. "Hot tub lung" is a recently described form of granulomatous interstitial pneumonia that appears to have some features of diffuse infections and some features of hypersensitivity pneumonitis. The pathologist's approach to these conditions can be facilitated by giving careful attention to the anatomic distribution of the granulomas, the qualitative features of the granulomas, and the histologic changes in the lung tissue around and away from the granulomas. These features, along with the results of cultures and special stains for micro-organisms and clinical and radiologic correlation allow for a diagnosis in the vast majority of cases.

Original languageEnglish (US)
Pages (from-to)127-138
Number of pages12
JournalAnnals of Diagnostic Pathology
Issue number2
StatePublished - Apr 2003


  • Granuloma
  • Hypersensitivity pneumonitis
  • Infection
  • Interstitial pneumonia
  • Sarcoid

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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