Supraspinal electrophysiological models for studying chronic pain

Long Jun Wu, Min Zhuo

Research output: Contribution to journalReview articlepeer-review


Electrophysiology has been intensively used in studying molecular mechanisms of pain transmission, modulation and plasticity. In vitro slice recordings provided detailed information on synaptic transmission and plasticity under both physiological and pathological pain conditions. In vivo recordings integrate the information of functional activities in the nociceptive pathway. Combination of electrophysiology with genetically manipulated mice, new behavioral models, in vivo/in vitro imaging and molecular biology will identify new molecular targets for controlling chronic pain in the future.

Original languageEnglish (US)
Pages (from-to)405-411
Number of pages7
JournalDrug Discovery Today: Disease Models
Issue number4
StatePublished - Dec 1 2006

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery


Dive into the research topics of 'Supraspinal electrophysiological models for studying chronic pain'. Together they form a unique fingerprint.

Cite this