Supraspinal electrophysiological models for studying chronic pain

Long Jun Wu; Min Zhuo

doi:10.1016/j.ddmod.2006.11.001

Supraspinal electrophysiological models for studying chronic pain

Long Jun Wu, Min Zhuo

Neurology

Research output: Contribution to journal › Review article › peer-review

Abstract

Electrophysiology has been intensively used in studying molecular mechanisms of pain transmission, modulation and plasticity. In vitro slice recordings provided detailed information on synaptic transmission and plasticity under both physiological and pathological pain conditions. In vivo recordings integrate the information of functional activities in the nociceptive pathway. Combination of electrophysiology with genetically manipulated mice, new behavioral models, in vivo/in vitro imaging and molecular biology will identify new molecular targets for controlling chronic pain in the future.

Original language	English (US)
Pages (from-to)	405-411
Number of pages	7
Journal	Drug Discovery Today: Disease Models
Volume	3
Issue number	4
DOIs	https://doi.org/10.1016/j.ddmod.2006.11.001
State	Published - Dec 1 2006

ASJC Scopus subject areas

Molecular Medicine
Drug Discovery

Access to Document

10.1016/j.ddmod.2006.11.001

Cite this

@article{58f3dbfcee8c42d5853e1c86ea3128ea,

title = "Supraspinal electrophysiological models for studying chronic pain",

abstract = "Electrophysiology has been intensively used in studying molecular mechanisms of pain transmission, modulation and plasticity. In vitro slice recordings provided detailed information on synaptic transmission and plasticity under both physiological and pathological pain conditions. In vivo recordings integrate the information of functional activities in the nociceptive pathway. Combination of electrophysiology with genetically manipulated mice, new behavioral models, in vivo/in vitro imaging and molecular biology will identify new molecular targets for controlling chronic pain in the future.",

author = "Wu, {Long Jun} and Min Zhuo",

year = "2006",

month = dec,

day = "1",

doi = "10.1016/j.ddmod.2006.11.001",

language = "English (US)",

volume = "3",

pages = "405--411",

journal = "Drug Discovery Today: Disease Models",

issn = "1740-6757",

publisher = "Elsevier Limited",

number = "4",

}

TY - JOUR

T1 - Supraspinal electrophysiological models for studying chronic pain

AU - Wu, Long Jun

AU - Zhuo, Min

PY - 2006/12/1

Y1 - 2006/12/1

N2 - Electrophysiology has been intensively used in studying molecular mechanisms of pain transmission, modulation and plasticity. In vitro slice recordings provided detailed information on synaptic transmission and plasticity under both physiological and pathological pain conditions. In vivo recordings integrate the information of functional activities in the nociceptive pathway. Combination of electrophysiology with genetically manipulated mice, new behavioral models, in vivo/in vitro imaging and molecular biology will identify new molecular targets for controlling chronic pain in the future.

AB - Electrophysiology has been intensively used in studying molecular mechanisms of pain transmission, modulation and plasticity. In vitro slice recordings provided detailed information on synaptic transmission and plasticity under both physiological and pathological pain conditions. In vivo recordings integrate the information of functional activities in the nociceptive pathway. Combination of electrophysiology with genetically manipulated mice, new behavioral models, in vivo/in vitro imaging and molecular biology will identify new molecular targets for controlling chronic pain in the future.

UR - http://www.scopus.com/inward/record.url?scp=33846657184&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33846657184&partnerID=8YFLogxK

U2 - 10.1016/j.ddmod.2006.11.001

DO - 10.1016/j.ddmod.2006.11.001

M3 - Review article

SN - 1740-6757

VL - 3

SP - 405

EP - 411

JO - Drug Discovery Today: Disease Models

JF - Drug Discovery Today: Disease Models

IS - 4

ER -

Supraspinal electrophysiological models for studying chronic pain

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this