Suppressive Therapy with Levothyroxine for Solitary Thyroid Nodules

Stephen J. Gordon, Julio C. Pita, Nelson B. Watts, Craig B. Wexler, Gary M. Pepper, Rachelle N. Bitton, Bruce S. Schneider, Joel I. Hamburger, Chiara Galli, Francesca Calasso, Giorgio Cantù, Luigi Carini, Paolo Rumi, Giovanni Segalini, Hossein Gharib, E. Meredith James, J. William Charboneau, James M. Naessens, Kenneth P. Offord, Colum A. Gorman

Research output: Contribution to journalLetterpeer-review

7 Scopus citations


To the Editor: The documentation by Gharib et al. (July 9 issue)* of the absence of change in thyroid nodules treated with levothyroxine over a six-month period comes as no surprise. It has been my distinct impression that in approximately 20 to 25 percent of patients, cold thyroid nodules suppressed with levothyroxine will show some shrinkage, but usually this is not apparent for one to two years and, in general, no change can be discerned at six months. I hope therefore that the authors will continue their study for several years to document whether this clinical impression of mine, and.

Original languageEnglish (US)
Pages (from-to)1663-1665
Number of pages3
JournalNew England Journal of Medicine
Issue number26
StatePublished - Dec 24 1987

ASJC Scopus subject areas

  • General Medicine


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