Super enhancers–new analyses and perspectives on the low hanging fruit

Feda H. Hamdan; Steven A. Johnsen

doi:10.1080/21541264.2017.1372044

Super enhancers–new analyses and perspectives on the low hanging fruit

Feda H. Hamdan, Steven A. Johnsen

Gastroenterology and Hepatology

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

Abstract

Significant attention has recently been given to a class of enhancers termed “super enhancers”, while implying that “typical enhancers” are less important. In this report, we examine criteria for identification of super enhancers and address the need to evaluate the differences between BRD4-occupied “typical” and “super” enhancers.

Original language	English (US)
Pages (from-to)	123-130
Number of pages	8
Journal	Transcription
Volume	9
Issue number	2
DOIs	https://doi.org/10.1080/21541264.2017.1372044
State	Published - Mar 15 2018

Keywords

BRD4
ERα activation
ROSE algorithm
enhancer RNA
super enhancers
transcriptional regulation
typical enhancers

ASJC Scopus subject areas

Biotechnology
Biochemistry
Genetics

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10.1080/21541264.2017.1372044

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title = "Super enhancers–new analyses and perspectives on the low hanging fruit",

abstract = "Significant attention has recently been given to a class of enhancers termed “super enhancers”, while implying that “typical enhancers” are less important. In this report, we examine criteria for identification of super enhancers and address the need to evaluate the differences between BRD4-occupied “typical” and “super” enhancers.",

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author = "Hamdan, {Feda H.} and Johnsen, {Steven A.}",

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AU - Johnsen, Steven A.

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AB - Significant attention has recently been given to a class of enhancers termed “super enhancers”, while implying that “typical enhancers” are less important. In this report, we examine criteria for identification of super enhancers and address the need to evaluate the differences between BRD4-occupied “typical” and “super” enhancers.

KW - BRD4

KW - ERα activation

KW - ROSE algorithm

KW - enhancer RNA

KW - super enhancers

KW - transcriptional regulation

KW - typical enhancers

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JF - Transcription

IS - 2

ER -

Super enhancers–new analyses and perspectives on the low hanging fruit

Abstract

Keywords

ASJC Scopus subject areas

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