1H MR spectroscopy in common dementias

K. Kantarci; R. C. Petersen; B. F. Boeve; D. S. Knopman; D. F. Tang-Wai; P. C. O'Brien; S. D. Weigand; S. D. Edland; G. E. Smith; R. J. Ivnik; T. J. Ferman; E. G. Tangalos; C. R. Jack

doi:10.1212/01.WNL.0000141849.21256.AC

¹H MR spectroscopy in common dementias

K. Kantarci, R. C. Petersen, B. F. Boeve, D. S. Knopman, D. F. Tang-Wai, P. C. O'Brien, S. D. Weigand, S. D. Edland, G. E. Smith, R. J. Ivnik, T. J. Ferman, E. G. Tangalos, C. R. Jack

Research output: Contribution to journal › Article › peer-review

194 Scopus citations

Abstract

Objective: To determine the ¹H MR spectroscopic (MRS) findings and intergroup differences among common dementias: Alzheimer disease (AD), vascular dementia (VaD), dementia with Lewy bodies (DLB), and frontotemporal lobar degeneration (FTLD). Methods: The authors consecutively recruited 206 normal elderly subjects and 121 patients with AD, 41 with FTLD, 20 with DLB, and 8 with VaD. The ¹H MRS metabolite ratio changes in common dementias were evaluated with respect to normal and also differences among the common dementias. Results: N-Acetylaspartate (NAA)/ creatine (Cr) was lower than normal in patients with AD, FTLD, and VaD. Myo-inositol (mI)/Cr was higher than normal in patients with AD and FTLD. Choline (Cho)/Cr was higher than normal in patients with AD, FTLD, and DLB. There were no metabolite differences between patients with AD and FTLD or between patients with DLB and VaD. NAA/Cr was lower in patients with AD and FTLD than DLB. MI/Cr was higher in patients with AD and FTLD than VaD. NAA/Cr was also higher in patients with FTLD than DLB. Conclusions: NAA/Cr levels are decreased in dementias that are characterized by neuron loss, such as AD, FTLD, and VaD. MI/Cr levels are elevated in dementias that are pathologically characterized by gliosis, such as AD and FTLD. Cho/Cr levels are elevated in dementias that are characterized by a profound cholinergic deficit, such as AD and DLB.

Original language	English (US)
Pages (from-to)	1393-1398
Number of pages	6
Journal	Neurology
Volume	63
Issue number	8
DOIs	https://doi.org/10.1212/01.WNL.0000141849.21256.AC
State	Published - Oct 26 2004

ASJC Scopus subject areas

Clinical Neurology

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title = "1H MR spectroscopy in common dementias",

abstract = "Objective: To determine the 1H MR spectroscopic (MRS) findings and intergroup differences among common dementias: Alzheimer disease (AD), vascular dementia (VaD), dementia with Lewy bodies (DLB), and frontotemporal lobar degeneration (FTLD). Methods: The authors consecutively recruited 206 normal elderly subjects and 121 patients with AD, 41 with FTLD, 20 with DLB, and 8 with VaD. The 1H MRS metabolite ratio changes in common dementias were evaluated with respect to normal and also differences among the common dementias. Results: N-Acetylaspartate (NAA)/ creatine (Cr) was lower than normal in patients with AD, FTLD, and VaD. Myo-inositol (mI)/Cr was higher than normal in patients with AD and FTLD. Choline (Cho)/Cr was higher than normal in patients with AD, FTLD, and DLB. There were no metabolite differences between patients with AD and FTLD or between patients with DLB and VaD. NAA/Cr was lower in patients with AD and FTLD than DLB. MI/Cr was higher in patients with AD and FTLD than VaD. NAA/Cr was also higher in patients with FTLD than DLB. Conclusions: NAA/Cr levels are decreased in dementias that are characterized by neuron loss, such as AD, FTLD, and VaD. MI/Cr levels are elevated in dementias that are pathologically characterized by gliosis, such as AD and FTLD. Cho/Cr levels are elevated in dementias that are characterized by a profound cholinergic deficit, such as AD and DLB.",

author = "K. Kantarci and Petersen, {R. C.} and Boeve, {B. F.} and Knopman, {D. S.} and Tang-Wai, {D. F.} and O'Brien, {P. C.} and Weigand, {S. D.} and Edland, {S. D.} and Smith, {G. E.} and Ivnik, {R. J.} and Ferman, {T. J.} and Tangalos, {E. G.} and Jack, {C. R.}",

year = "2004",

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day = "26",

doi = "10.1212/01.WNL.0000141849.21256.AC",

language = "English (US)",

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T1 - 1H MR spectroscopy in common dementias

AU - Kantarci, K.

AU - Petersen, R. C.

AU - Boeve, B. F.

AU - Knopman, D. S.

AU - Tang-Wai, D. F.

AU - O'Brien, P. C.

AU - Weigand, S. D.

AU - Edland, S. D.

AU - Smith, G. E.

AU - Ivnik, R. J.

AU - Ferman, T. J.

AU - Tangalos, E. G.

AU - Jack, C. R.

PY - 2004/10/26

Y1 - 2004/10/26

N2 - Objective: To determine the 1H MR spectroscopic (MRS) findings and intergroup differences among common dementias: Alzheimer disease (AD), vascular dementia (VaD), dementia with Lewy bodies (DLB), and frontotemporal lobar degeneration (FTLD). Methods: The authors consecutively recruited 206 normal elderly subjects and 121 patients with AD, 41 with FTLD, 20 with DLB, and 8 with VaD. The 1H MRS metabolite ratio changes in common dementias were evaluated with respect to normal and also differences among the common dementias. Results: N-Acetylaspartate (NAA)/ creatine (Cr) was lower than normal in patients with AD, FTLD, and VaD. Myo-inositol (mI)/Cr was higher than normal in patients with AD and FTLD. Choline (Cho)/Cr was higher than normal in patients with AD, FTLD, and DLB. There were no metabolite differences between patients with AD and FTLD or between patients with DLB and VaD. NAA/Cr was lower in patients with AD and FTLD than DLB. MI/Cr was higher in patients with AD and FTLD than VaD. NAA/Cr was also higher in patients with FTLD than DLB. Conclusions: NAA/Cr levels are decreased in dementias that are characterized by neuron loss, such as AD, FTLD, and VaD. MI/Cr levels are elevated in dementias that are pathologically characterized by gliosis, such as AD and FTLD. Cho/Cr levels are elevated in dementias that are characterized by a profound cholinergic deficit, such as AD and DLB.

AB - Objective: To determine the 1H MR spectroscopic (MRS) findings and intergroup differences among common dementias: Alzheimer disease (AD), vascular dementia (VaD), dementia with Lewy bodies (DLB), and frontotemporal lobar degeneration (FTLD). Methods: The authors consecutively recruited 206 normal elderly subjects and 121 patients with AD, 41 with FTLD, 20 with DLB, and 8 with VaD. The 1H MRS metabolite ratio changes in common dementias were evaluated with respect to normal and also differences among the common dementias. Results: N-Acetylaspartate (NAA)/ creatine (Cr) was lower than normal in patients with AD, FTLD, and VaD. Myo-inositol (mI)/Cr was higher than normal in patients with AD and FTLD. Choline (Cho)/Cr was higher than normal in patients with AD, FTLD, and DLB. There were no metabolite differences between patients with AD and FTLD or between patients with DLB and VaD. NAA/Cr was lower in patients with AD and FTLD than DLB. MI/Cr was higher in patients with AD and FTLD than VaD. NAA/Cr was also higher in patients with FTLD than DLB. Conclusions: NAA/Cr levels are decreased in dementias that are characterized by neuron loss, such as AD, FTLD, and VaD. MI/Cr levels are elevated in dementias that are pathologically characterized by gliosis, such as AD and FTLD. Cho/Cr levels are elevated in dementias that are characterized by a profound cholinergic deficit, such as AD and DLB.

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DO - 10.1212/01.WNL.0000141849.21256.AC

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AN - SCOPUS:7044220330

SN - 0028-3878

VL - 63

SP - 1393

EP - 1398

JO - Neurology

JF - Neurology

IS - 8

ER -

¹H MR spectroscopy in common dementias

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