Successful treatment of Whipple disease diagnosed 36 years after symptom onset

Sean M. Caples, Lydia M. Petrovic, Jay H. Ryu

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Whipple disease is a rare infectious disorder with multiorgan manifestations and a widely varied clinical presentation. Involvement of the small intestine with resultant malabsorption is a classic finding, although extraintestinal manifestations such as fever and arthralgias may precede gastrointestinal symptoms by many years. We describe a 63-year-old man in whom Whipple disease was diagnosed 22 years after his initial presentation (36 years after symptom onset) with lymphadenopathy, when a biopsy yielded nonnecrotizing granulomas. His recent symptoms included persistent fatigue, weight loss, fever, and arthralgias. Endoscopic biopsy specimens from the distal duodenum showed features consistent with Whipple disease, and Tropheryma whippelii DNA was detected in both the small bowel biopsy specimen and the blood specimen by polymerase chain reaction and DNA probe hybridization. His symptoms resolved with long-term co-trimoxazole therapy. We discuss the protean manifestations of Whipple disease, the difficulties in clinical diagnosis, and the recent advances in the molecular diagnosis of this disorder.

Original languageEnglish (US)
Article number62493
Pages (from-to)1063-1066
Number of pages4
JournalMayo Clinic proceedings
Issue number10
StatePublished - Oct 2001


  • MCV = mean corpuscular volume
  • PAS = periodic acid-Schiff
  • PCR = polymerase chain reaction

ASJC Scopus subject areas

  • Medicine(all)


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