Abstract
Relapse is the major cause of treatment failure after allogeneic transplantation of children with juvenile myelomonocytic leukemia (JMML), and the role of post-transplant immunomodulation is poorly understood. We report a 12-month-old child with JMML relapsed after unrelated marrow transplantation who received cytoreduction followed by donor lymphocyte infusion (DLI) with improvement, and after addition of interferon-alpha (IFN) achieved complete donor chimerism. He was weaned from IFN and has maintained complete remission for 19 months. This is the first published report of a patient with non-monosomy-7 JMML responding to post-transplant immunomodulation and suggests a role for DLI plus IFN in these patients.
Original language | English (US) |
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Pages (from-to) | 113-115 |
Number of pages | 3 |
Journal | Bone Marrow Transplantation |
Volume | 33 |
Issue number | 1 |
DOIs | |
State | Published - Jan 2004 |
Keywords
- Allogeneic stem cell transplantation
- Donor lymphocyte infusion (DLI)
- Graft-versus-leukemia (GVL)
- Interferon-alpha
- Juvenile myleomonocytic leukemia (JMML)
ASJC Scopus subject areas
- Hematology
- Transplantation