Successful treatment of a case of late-onset colitis after umbilical cord transplantation with metronidazole: A case report and literature review

Reona Sakemura; Hiroshi Hayakawa; Hiroatsu Iida; Masafumi Ito; Tomohiro Kajiguchi

doi:10.2169/internalmedicine.8948-17

Successful treatment of a case of late-onset colitis after umbilical cord transplantation with metronidazole: A case report and literature review

Reona Sakemura, Hiroshi Hayakawa, Hiroatsu Iida, Masafumi Ito, Tomohiro Kajiguchi

Hematology

Research output: Contribution to journal › Review article › peer-review

Abstract

Diarrhea after hematopoietic stem cell transplantation (HSCT) can be life-threatening, and its etiology includes conditioning regimens, graft-versus-host disease (GVHD), infections, and transplantation-associated microangiopathy (iTAM). Cord colitis syndrome (CCS) has been described as a syndrome of culture-negative and antibiotic-responsive persistent watery and non-bloody diarrhea of uncertain pathogenesis and occurs in umbilical cord blood transplantation (UCBT) recipients. We encountered a case similar to CCS that developed severe watery diarrhea after UCBT without any signs of GVHD or infection and responded well to metronidazole (MNZ) treatment. Since CCS is very rare, we herein describe a case of MNZ-effective diarrhea after UCBT.

Original language	English (US)
Pages (from-to)	3219-3223
Number of pages	5
Journal	Internal Medicine
Volume	56
Issue number	23
DOIs	https://doi.org/10.2169/internalmedicine.8948-17
State	Published - 2017

Keywords

Cord colitis syndrome (CCS)
Metronidazole (MNZ)
Umbilical cord blood (UCB)
Watery diarrhea

ASJC Scopus subject areas

Internal Medicine

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10.2169/internalmedicine.8948-17

Cite this

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title = "Successful treatment of a case of late-onset colitis after umbilical cord transplantation with metronidazole: A case report and literature review",

abstract = "Diarrhea after hematopoietic stem cell transplantation (HSCT) can be life-threatening, and its etiology includes conditioning regimens, graft-versus-host disease (GVHD), infections, and transplantation-associated microangiopathy (iTAM). Cord colitis syndrome (CCS) has been described as a syndrome of culture-negative and antibiotic-responsive persistent watery and non-bloody diarrhea of uncertain pathogenesis and occurs in umbilical cord blood transplantation (UCBT) recipients. We encountered a case similar to CCS that developed severe watery diarrhea after UCBT without any signs of GVHD or infection and responded well to metronidazole (MNZ) treatment. Since CCS is very rare, we herein describe a case of MNZ-effective diarrhea after UCBT.",

keywords = "Cord colitis syndrome (CCS), Metronidazole (MNZ), Umbilical cord blood (UCB), Watery diarrhea",

author = "Reona Sakemura and Hiroshi Hayakawa and Hiroatsu Iida and Masafumi Ito and Tomohiro Kajiguchi",

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T2 - A case report and literature review

AU - Sakemura, Reona

AU - Hayakawa, Hiroshi

AU - Iida, Hiroatsu

AU - Ito, Masafumi

AU - Kajiguchi, Tomohiro

PY - 2017

Y1 - 2017

N2 - Diarrhea after hematopoietic stem cell transplantation (HSCT) can be life-threatening, and its etiology includes conditioning regimens, graft-versus-host disease (GVHD), infections, and transplantation-associated microangiopathy (iTAM). Cord colitis syndrome (CCS) has been described as a syndrome of culture-negative and antibiotic-responsive persistent watery and non-bloody diarrhea of uncertain pathogenesis and occurs in umbilical cord blood transplantation (UCBT) recipients. We encountered a case similar to CCS that developed severe watery diarrhea after UCBT without any signs of GVHD or infection and responded well to metronidazole (MNZ) treatment. Since CCS is very rare, we herein describe a case of MNZ-effective diarrhea after UCBT.

AB - Diarrhea after hematopoietic stem cell transplantation (HSCT) can be life-threatening, and its etiology includes conditioning regimens, graft-versus-host disease (GVHD), infections, and transplantation-associated microangiopathy (iTAM). Cord colitis syndrome (CCS) has been described as a syndrome of culture-negative and antibiotic-responsive persistent watery and non-bloody diarrhea of uncertain pathogenesis and occurs in umbilical cord blood transplantation (UCBT) recipients. We encountered a case similar to CCS that developed severe watery diarrhea after UCBT without any signs of GVHD or infection and responded well to metronidazole (MNZ) treatment. Since CCS is very rare, we herein describe a case of MNZ-effective diarrhea after UCBT.

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KW - Metronidazole (MNZ)

KW - Umbilical cord blood (UCB)

KW - Watery diarrhea

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Successful treatment of a case of late-onset colitis after umbilical cord transplantation with metronidazole: A case report and literature review

Abstract

Keywords

ASJC Scopus subject areas

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