Successful intravenous thrombolysis in ischemic stroke caused by infective endocarditis

Mithri Junna, Chang Ching D. Lin, Raul E. Espinosa, Alejandro A. Rabinstein

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


Introduction: Infective endocarditis can lead to serious neurological complications including ischemic stroke and intracranial hemorrhage. Treatment with intravenous thrombolysis within 3 h of symptom onset has become the standard of care in acute ischemic stroke, but the safety and efficacy of this intervention in patients with infective endocarditis is unknown. Summary of Case: We report the case of a patient with ischemic stroke who experienced substantial neurological improvement after being treated with intravenous thrombolysis (NIH stroke scale score of 15 on admission and 4 after treatment) and was subsequently found to have acute infective mitral endocarditis. Conclusion: Favorable response to thrombolysis may occur in patients with stroke due to infectious endocarditis. The safety of this therapy remains to be established.

Original languageEnglish (US)
Pages (from-to)117-120
Number of pages4
JournalNeurocritical care
Issue number2
StatePublished - Apr 2007


  • Infective endocarditis
  • Stroke
  • Thrombolysis

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Clinical Neurology


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