@article{fed4636260d8434b9274446973ca6eb3,
title = "Submentalis Rapid Eye Movement Sleep Muscle Activity: A Potential Biomarker for Synucleinopathy",
abstract = "Accurate antemortem diagnosis of parkinsonism is primarily based on clinical evaluation with limited biomarkers. We evaluated the diagnostic utility of quantitative rapid eye movement (REM) sleep without atonia analysis in the submentalis and anterior tibialis muscles in parkinsonian patients (53 synucleinopathy, 24 tauopathy). Receiver operating characteristic curves determined REM sleep without atonia cutoffs distinguishing synucleinopathies from tauopathies. Elevated submentalis muscle activity was highly sensitive (70–77%) and specific (95–100%) in distinguishing synucleinopathy from tauopathy. In contrast, anterior tibialis synucleinopathy discrimination was poor. Our results suggest that elevated submentalis REM sleep without atonia appears to be a potentially useful biomarker for presumed synucleinopathy etiologies in parkinsonism. ANN NEUROL 2019;86:969–974.",
author = "McCarter, {Stuart J.} and Feemster, {John C.} and Tabatabai, {Grace M.} and Sandness, {David J.} and Timm, {Paul C.} and McCarter, {Allison R.} and Talley, {Heather N.} and Junna, {Mithri R.} and Rodolfo Savica and Wolfgang Singer and Coon, {Elizabeth A.} and Benarroch, {Eduardo E.} and Josephs, {Keith A.} and Boeve, {Bradley F.} and Silber, {Michael H.} and {St. Louis}, {Erik K.}",
note = "Funding Information: The project described was supported by a Parkinson's Disease Foundation–American Parkinson Disease Association (PDF‐APDA) summer student fellowship (PDF‐APDA‐SFW‐1656); a Mayo Clinic Alzheimer's Disease Research Center grant award from the NIH National Institute on Aging (P50 AG016574); and the NIH National Center for Research Resources and NIH National Center for Advancing Translational Sciences (1 UL1 RR024150‐01); and the NIH National Institute on Aging (R34AG056639). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH or PDF‐APDA. We thank L. Dacy for her assistance with manuscript formatting and submission. Funding Information: The project described was supported by a Parkinson's Disease Foundation?American Parkinson Disease Association (PDF-APDA) summer student fellowship (PDF-APDA-SFW-1656); a Mayo Clinic Alzheimer's Disease Research Center grant award from the NIH National Institute on Aging (P50 AG016574); and the NIH National Center for Research Resources and NIH National Center for Advancing Translational Sciences (1 UL1 RR024150-01); and the NIH National Institute on Aging (R34AG056639). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH or PDF-APDA. We thank L. Dacy for her assistance with manuscript formatting and submission. Publisher Copyright: {\textcopyright} 2019 American Neurological Association",
year = "2019",
month = dec,
day = "1",
doi = "10.1002/ana.25622",
language = "English (US)",
volume = "86",
pages = "969--974",
journal = "Annals of neurology",
issn = "0364-5134",
publisher = "John Wiley and Sons Inc.",
number = "6",
}