Subclinical hypothyroidism and subclinical hyperthyroidism

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4 Scopus citations


Subclinical thyroid dysfunction occurs when peripheral thyroid hormone levels are within the normal laboratory reference range and the serum thyroid-stimulating hormone (TSH or thyrotropin) level is greater than normal (subclinical hypothyroidism) or less than normal (subclinical hyperthyroidism; TSH normal laboratory reference range: 0.3-5.0 mIU/l). For patients with subclinical hypothyroidism (serum TSH levels >10 mIU/l), thyroxine therapy is prescribed if other causes of TSH elevation and transient conditions have been excluded. For serum TSH levels between 5.0 and 10.0 mIU/l, selective therapy should be considered. For patients with sustained subclinical hyperthyroidism (serum TSH levels <0.1 mIU/l), therapy is recommended, especially in older patients. Observation or selective therapy should be considered for patients with serum TSH levels between 0.1 and 0.3 mIU/l.

Original languageEnglish (US)
Pages (from-to)359-373
Number of pages15
JournalExpert Review of Endocrinology and Metabolism
Issue number3
StatePublished - May 2010


  • Antithyroid antibody
  • Cardiac risk factor
  • Hyperthyroidism
  • Hypothyroidism
  • Subclinical hyperthyroidism
  • Subclinical hypothyroidism
  • Thyroid-stimulating hormone screening
  • Thyrotropin
  • Thyroxine therapy

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism


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