Subcellular distribution of aromatase in human placenta and ovary

E. A. Thompson, P. K. Siiteri

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


The aromatization of androstenedione in human ovarian microsomes is inhibited by an antibody to porcine hepatic microsomal NADPH-cytochrome c reductase. Likewise, the antibody inhibits aromatization in mitochondria isolated from human ovaries and placentae. A given quantity of the antibody produces the same percent inhibition of aromatization in microsomes and mitochondria of both ovaries and placentae. These data, in addition to the low specific activity observed for the mitochondrial aromatase, indicate that aromatization in mitochondria probably results from microsomal contamination.

Original languageEnglish (US)
Pages (from-to)179-185
Number of pages7
JournalHormone Research
Issue number4
StatePublished - 1979

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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