TY - JOUR
T1 - Subacute sclerosing panencephalitis is typically characterized by alterations in the fusion protein cytoplasmic domain of the persisting measles virus
AU - Schmid, Anita
AU - Spielhofer, Pius
AU - Cattaneo, Roberto
AU - Baczko, Knut
AU - Ter Meulen, Volker
AU - Billeter, Martin A.
N1 - Funding Information:
We thank Fritz Ochsenbein for graphic work and Karin Kaelin for critical reading of the manuscript. This research was supported by Grant 31-9434.88 of the Schweizerische Nationalfonds, by the Kan-ton Zurich, and by the Deutsche Forschungsgemeinschaft, Bundes-ministerium fijr Forschung und Technologie.
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1992/6
Y1 - 1992/6
N2 - Our recent extensive analysis of three cases of subacute sclerosing panencephalitis (SSPE) revealed intriguing genetic defects in the persisting measles virus (MV): the fusion (F) genes encoded truncated cytoplasmic F protein domains (Cattaneo et al., Virology 173, 415-425, 1989). Now this MV genomic region has been investigated in eight additional SSPE cases by PCR amplification, replacement cloning into a vector containing the F gene of a lytic MV, in vitro expression, and sequencing. In all cases at least part of the clones showed mutations leading to F protein truncations, elongation, or nonconservative amino acid replacements. It is proposed that alteration of the F protein cytoplasmic domain may play a critical role in the development of SSPE.
AB - Our recent extensive analysis of three cases of subacute sclerosing panencephalitis (SSPE) revealed intriguing genetic defects in the persisting measles virus (MV): the fusion (F) genes encoded truncated cytoplasmic F protein domains (Cattaneo et al., Virology 173, 415-425, 1989). Now this MV genomic region has been investigated in eight additional SSPE cases by PCR amplification, replacement cloning into a vector containing the F gene of a lytic MV, in vitro expression, and sequencing. In all cases at least part of the clones showed mutations leading to F protein truncations, elongation, or nonconservative amino acid replacements. It is proposed that alteration of the F protein cytoplasmic domain may play a critical role in the development of SSPE.
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U2 - 10.1016/0042-6822(92)90552-Z
DO - 10.1016/0042-6822(92)90552-Z
M3 - Article
C2 - 1585658
AN - SCOPUS:0026772612
SN - 0042-6822
VL - 188
SP - 910
EP - 915
JO - Virology
JF - Virology
IS - 2
ER -