Study of association between antibodies to non-HLA kidney self-antigens and progression to chronic immune injury after kidney transplantation

Sumi Nair; Ranjithkumar Ravichandran; Raymond Heilman; Andrés Jaramillo; Matthew Buras; Bruce Kaplan; Yoshihiro Itabashi; Daniel Ramon; Katrin Hacke; Byron Smith; Thalachallour Mohanakumar

doi:10.1016/j.humimm.2023.07.006

Study of association between antibodies to non-HLA kidney self-antigens and progression to chronic immune injury after kidney transplantation

Sumi Nair, Ranjithkumar Ravichandran, Raymond Heilman, Andrés Jaramillo, Matthew Buras, Bruce Kaplan, Yoshihiro Itabashi, Daniel Ramon, Katrin Hacke, Byron Smith, Thalachallour Mohanakumar

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Immune response to several kidney self-antigens (KSAg) such as Collagen IV (Col-IV), Perlecan (PL), and Fibronectin (FN) have been associated with antibody-mediated damage and poor allograft survival. Thus, the aim of this study was to determine if humoral immune responses to KSAg correlates with progression of chronic immune injury (CII) changes at 1 year or 2 years. Methods: Kidney transplant recipients who underwent 1- or 2-year biopsies, with chronic interstitial inflammation (ci > 1) and/or glomerular membrane double contouring (cg > 0) were analyzed with matched controls. Sera were analyzed retrospectively for antibodies against KSAg using ELISA. The presence of antibodies to KSAg were compared at 0, 4, 12, and 24 months using logistic regression. Results: We identified a cohort of 214 kidney transplant recipients. Of these, we identified 33 cases and matched 66 controls. Logistical regression showed an odds ratio of 1 with the confidence interval crossing 1 for the presence of response to KSAg at all the time points. Conclusions: Humoral immune responses to either KSAg alone or in combination with donor-specific anti-HLA antibodies are not associated with progression to CII at 1 and 2 years after kidney transplantation.

Original language	English (US)
Pages (from-to)	509-514
Number of pages	6
Journal	Human Immunology
Volume	84
Issue number	10
DOIs	https://doi.org/10.1016/j.humimm.2023.07.006
State	Published - Oct 2023

Keywords

Chronic immune injury
Chronic rejection
Collagen IV
Fibronectin
IFTA
Immune Injury
Interstitial fibrosis tubular atrophy
Kidney self-antigens
Kidney transplant
Non-HLA antibodies
Perlecan
Transplant biopsy

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1016/j.humimm.2023.07.006

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Nair, S., Ravichandran, R., Heilman, R., Jaramillo, A., Buras, M., Kaplan, B., Itabashi, Y., Ramon, D., Hacke, K., Smith, B., & Mohanakumar, T. (2023). Study of association between antibodies to non-HLA kidney self-antigens and progression to chronic immune injury after kidney transplantation. Human Immunology, 84(10), 509-514. https://doi.org/10.1016/j.humimm.2023.07.006

Nair, S, Ravichandran, R, Heilman, R, Jaramillo, A, Buras, M, Kaplan, B, Itabashi, Y, Ramon, D, Hacke, K, Smith, B & Mohanakumar, T 2023, 'Study of association between antibodies to non-HLA kidney self-antigens and progression to chronic immune injury after kidney transplantation', Human Immunology, vol. 84, no. 10, pp. 509-514. https://doi.org/10.1016/j.humimm.2023.07.006

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title = "Study of association between antibodies to non-HLA kidney self-antigens and progression to chronic immune injury after kidney transplantation",

abstract = "Background: Immune response to several kidney self-antigens (KSAg) such as Collagen IV (Col-IV), Perlecan (PL), and Fibronectin (FN) have been associated with antibody-mediated damage and poor allograft survival. Thus, the aim of this study was to determine if humoral immune responses to KSAg correlates with progression of chronic immune injury (CII) changes at 1 year or 2 years. Methods: Kidney transplant recipients who underwent 1- or 2-year biopsies, with chronic interstitial inflammation (ci > 1) and/or glomerular membrane double contouring (cg > 0) were analyzed with matched controls. Sera were analyzed retrospectively for antibodies against KSAg using ELISA. The presence of antibodies to KSAg were compared at 0, 4, 12, and 24 months using logistic regression. Results: We identified a cohort of 214 kidney transplant recipients. Of these, we identified 33 cases and matched 66 controls. Logistical regression showed an odds ratio of 1 with the confidence interval crossing 1 for the presence of response to KSAg at all the time points. Conclusions: Humoral immune responses to either KSAg alone or in combination with donor-specific anti-HLA antibodies are not associated with progression to CII at 1 and 2 years after kidney transplantation.",

keywords = "Chronic immune injury, Chronic rejection, Collagen IV, Fibronectin, IFTA, Immune Injury, Interstitial fibrosis tubular atrophy, Kidney self-antigens, Kidney transplant, Non-HLA antibodies, Perlecan, Transplant biopsy",

author = "Sumi Nair and Ranjithkumar Ravichandran and Raymond Heilman and Andr{\'e}s Jaramillo and Matthew Buras and Bruce Kaplan and Yoshihiro Itabashi and Daniel Ramon and Katrin Hacke and Byron Smith and Thalachallour Mohanakumar",

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doi = "10.1016/j.humimm.2023.07.006",

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T1 - Study of association between antibodies to non-HLA kidney self-antigens and progression to chronic immune injury after kidney transplantation

AU - Nair, Sumi

AU - Ravichandran, Ranjithkumar

AU - Heilman, Raymond

AU - Jaramillo, Andrés

AU - Buras, Matthew

AU - Kaplan, Bruce

AU - Itabashi, Yoshihiro

AU - Ramon, Daniel

AU - Hacke, Katrin

AU - Smith, Byron

AU - Mohanakumar, Thalachallour

PY - 2023/10

Y1 - 2023/10

N2 - Background: Immune response to several kidney self-antigens (KSAg) such as Collagen IV (Col-IV), Perlecan (PL), and Fibronectin (FN) have been associated with antibody-mediated damage and poor allograft survival. Thus, the aim of this study was to determine if humoral immune responses to KSAg correlates with progression of chronic immune injury (CII) changes at 1 year or 2 years. Methods: Kidney transplant recipients who underwent 1- or 2-year biopsies, with chronic interstitial inflammation (ci > 1) and/or glomerular membrane double contouring (cg > 0) were analyzed with matched controls. Sera were analyzed retrospectively for antibodies against KSAg using ELISA. The presence of antibodies to KSAg were compared at 0, 4, 12, and 24 months using logistic regression. Results: We identified a cohort of 214 kidney transplant recipients. Of these, we identified 33 cases and matched 66 controls. Logistical regression showed an odds ratio of 1 with the confidence interval crossing 1 for the presence of response to KSAg at all the time points. Conclusions: Humoral immune responses to either KSAg alone or in combination with donor-specific anti-HLA antibodies are not associated with progression to CII at 1 and 2 years after kidney transplantation.

AB - Background: Immune response to several kidney self-antigens (KSAg) such as Collagen IV (Col-IV), Perlecan (PL), and Fibronectin (FN) have been associated with antibody-mediated damage and poor allograft survival. Thus, the aim of this study was to determine if humoral immune responses to KSAg correlates with progression of chronic immune injury (CII) changes at 1 year or 2 years. Methods: Kidney transplant recipients who underwent 1- or 2-year biopsies, with chronic interstitial inflammation (ci > 1) and/or glomerular membrane double contouring (cg > 0) were analyzed with matched controls. Sera were analyzed retrospectively for antibodies against KSAg using ELISA. The presence of antibodies to KSAg were compared at 0, 4, 12, and 24 months using logistic regression. Results: We identified a cohort of 214 kidney transplant recipients. Of these, we identified 33 cases and matched 66 controls. Logistical regression showed an odds ratio of 1 with the confidence interval crossing 1 for the presence of response to KSAg at all the time points. Conclusions: Humoral immune responses to either KSAg alone or in combination with donor-specific anti-HLA antibodies are not associated with progression to CII at 1 and 2 years after kidney transplantation.

KW - Chronic immune injury

KW - Chronic rejection

KW - Collagen IV

KW - Fibronectin

KW - IFTA

KW - Immune Injury

KW - Interstitial fibrosis tubular atrophy

KW - Kidney self-antigens

KW - Kidney transplant

KW - Non-HLA antibodies

KW - Perlecan

KW - Transplant biopsy

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SN - 0198-8859

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JO - Human Immunology

JF - Human Immunology

IS - 10

ER -

Study of association between antibodies to non-HLA kidney self-antigens and progression to chronic immune injury after kidney transplantation

Abstract

Keywords

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