Studies of twins in vaccinology

Robert M. Jacobson, Inna G. Ovsyannikova, Paul V. Targonski, Gregory A. Poland

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


In this survey, we review published investigations and trials of vaccines among twins. We identified 29 original studies, dating back to 1979. The studies include determinations of the role of genetics and environment in the variation in immune response to vaccination, the investigation of adverse events in which vaccination was the suspected etiologic agent, and the occurrence of vaccine preventable diseases or their complications. Specific methods include case reports, cross-sectional surveys, prospective surveys, and double-blind, randomized, placebo-controlled, cross-over studies. We examine three of these studies in detail to illustrate important opportunities and limitations of twins studies in vaccinology.

Original languageEnglish (US)
Pages (from-to)3160-3164
Number of pages5
Issue number16 SPEC. ISS.
StatePublished - Apr 20 2007


  • Twins
  • Vaccination
  • Vaccines

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases


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