Structure and function of the hepatitis B virus genome.

H. Will, C. Kuhn, R. Cattaneo, H. Schaller

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


A preliminary map of the hepatitis B virus genome has been derived from the nucleotide sequence of cloned human hepatitis virus (HBV) DNA. The genes for two viral antigens were identified and their expression was studied using SV40 vector systems. HBV DNA cloned and amplified in bacteria induces hepatitis in chimpanzees demonstrating that the cloned HBV DNA is functionally intact.

Original languageEnglish (US)
Pages (from-to)237-247
Number of pages11
JournalPrincess Takamatsu symposia
StatePublished - Dec 1 1982

ASJC Scopus subject areas

  • Medicine(all)


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