Abstract
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with one of the poorest prognosis among all malignancies. The initiation and evolution of this kind of tumor depends on a complex interaction between cancer cells and the tumor microenvironment (TME). In an elegant study, Steins et al [1] used a combination of relevant disease models to show that mesenchymal subtype of PDAC shows a distinct deactivation of stellate cells in a CSF1-dependent fashion. This study shedding light on a new role for the stroma driving an aggressive PDAC subtypes shifts the current paradigm for the requirement of an activated TME to regulate PDAC growth and maintenance.
Original language | English (US) |
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Article number | e50468 |
Journal | EMBO Reports |
Volume | 21 |
Issue number | 5 |
DOIs | |
State | Published - May 6 2020 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Genetics